Can hypertensions cause Peyronie’s disease?

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Dr. Levine answers: Hypertension has been associated with erectile dysfunction as it causes progressive injury to the blood vessels within the penis reducing the ability of those vessels to dilate in response to a sexual stimulus. Men who have compromised erections and who are also susceptible to Peyronie’s disease may injure their penis while trying to have intercourse with a soft erection. It may be that the buckling that occurs with a less rigid penis results in intratunical micro-trauma, which could activate the Peyronie’s process in the susceptible individual. One could think of this type of injury much like a metal fatigue fracture that happens from bending a piece of soft metal back and forth on multiple occasions until the metal fractures.