Causes

Is there any correlation between other autoimmune disorders, such as lichen planus for example, and the occurrence of PD, or the prognosis of the condition?

Dr. Mulhall answers: Many experts believe that there is some genetic and/or immunological facet to Peyronie’s disease. How else could we account for why some men get the condition and others do not? As with much else in Peyronie’s disease, there has been no real study of

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What causes waisting?

Dr. Mulhall answers: The penises affect by Peyronie’s disease present with variety of deformities. The type of deformity that an individual patient experiences depends on 3 major factors (1) the size of the plaque (2) the location of the plaque and (3) the elasticity of the tunica

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I have been riding a bicycle for 60+ years, and continue to ride daily. I often have penile numbness after a period of time in the saddle. Could this be a cause of PD, and cause further exacerbation of my PD? Do you have any recommendations on bicycle saddles, or bicycle types, that would hep reduce penile numbness/trauma? Thank you.

Sitting in the straddle position with pressure on the perineum can cause penile, scrotal, and urethral numbness; there is no evidence at this time that this causes Peyronie’s disease or would exacerbate underlying Peyronie’s disease. It is simply due to a pressure on blood vessels and nerves

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I had a piercing in my penis (a PA) a couple of years ago. When I had it stretched to 5 mm, it appears the “lump” in my penis and the bend occurred. Have you heard of this before? Is it coincidental?

Dr. Levine answers: Any traumatic event to the penis could possibly activate Peyronie’s disease in the susceptible individual. It is not exactly clear to me where your piercing is located on the penis, but usually it is in the area of the urethral opening of the penis

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After a biking trauma I have erectile dysfunction and pain when sitting. Erections are rare without desire and my penis is curved and sticks to my body. I am 22, do I suffer from PD?

Dr. Levine answers: The typical injury occurring with biking or any straddle sport is an injury to the vascular or nerve supply to the penis which can result in erectile dysfunction and/or a numb penis. The fact that there is pain may indicate a nerve entrapment. If

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I was kicked in the penis six weeks ago. I was diagnosed with Peyronie’s disease this week. I have not had intercourse in a year or more. Could the injury have caused the Peyronie’s disease?

Dr. Levine answers: It appears that the most common cause for triggering Peyronie’s disease is local trauma to the penis, which most commonly occurs during sexual activity when the penis is erect, but a man may develop Peyronie’s disease following a direct trauma to the penis that

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What are the implications of PD secondary to catheterization trauma as regards the causal factors of PD? Why would inflammation in the urethra lead to PD? Why would injury to a separated part of the penis find its way to the tunica?

Dr. Mulhall answers: There exists no evidence that urethral catheterization causes Peyronie’s disease. Indeed, as you point out the “injury” would be remote from where the vast majority of the plaques are located. It is likely that the trauma that is implicated in Peyronie’s disease development is

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Since trauma and micro-trauma are widely accepted as a major cause of PD, what is believed to be the level of risk from intralesional verapamil (ILV) treatments? Also, does the aging process make the tunica more subject to damage from ILV treatments?

Dr. Mulhall answers: This is an excellent and frequently asked question. There is no indication that ILV causes more trauma and the evidence for this is that many men have stabilization or improvement of the Peyronie’s disease when they have used ILV. Likewise, there is no evidence

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In any of the cases you’ve seen, is stress indicated as a possible trigger for Peyronie’s? I ask, because in me its appearance coincided with a very stressful period of my life.

Dr. Levine answers: Stress can certainly be a contributing factor to many disorders. It is unlikely to activate the Peyronie’s process directly, but stress may result in diminished rigidity which may subject the “at risk” penis to a greater likelihood of injury which would then activate the

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