Nonsurgical Treatment

I have heard that vitamin E is the only known treatment. Is that correct? If so, can it be taken by injection for more effectiveness? Is there stem cell research going on for Peyronie’s disease, and is it possible to get involved with it?

Vitamin E is one of the first oral agents used for the treatment of PD. However, there is no convincing evidence that alone or in combination with other agents it is of any significant benefit. Its use advocated by generations of urologists without any real understanding of

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I have been diagnosed with early stage PD (no noticeable curvature). I have been taking Potaba, acetyl-l carnitine and vitamin E for about a month with some moderate improvement in pain. I recently saw a specialist in PD who said I should be taking a combination of Trental, L-arginine and Viagra. Have you heard that the latter combination is effective? I am very concerned about taking Viagra on a daily basis and have not had any ED problems.

Firstly, how we should be treating men in your stage of the condition is unknown. Any advice you receive from a PD expert is based on personal opinion and not on real evidence. There is experimental evidence that pentoxifylline and Viagra may do “good things” to PD

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Hand surgeons for Dupuytren’s contractures have been successfully using an open percutaneous needle fasciotomy procedure instead of an open procedure. Why can’t this closed percutaneous technique be a procedure used by urologists for Peyronie’s patients?

This is a good question and in fact Dr. Levine has had direct contact with the physician in Florida who has championed this approach. Unfortunately the situation is different in Peyronie’s disease in that with Dupuytren’s the scar tissue attaches to the underlying tissue causing the tethered

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Is it true that PD plaque (scar tissue) needs to be visualized by an ultrasound in order to perform verapamil injections?

No, verapamil injections can certainly begin without an ultrasound, but an ultrasound does provide information as to whether there is extensive calcification in the plaque. A large sheet of bone will make intralesional injection of any drug result in little benefit as the needle cannot penetrate the

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I have an aggressive case of PD and I am an avid bodybuilder and weight lifter. Will penile traction therapy work for me? I do not want to take any oral medications. What traction system holds the most promise?

This is a good question as it pertains to recent research. A pilot study was completed in Chicago examining the effects of penile traction therapy with the FastSize penile extender (FastSize.com). This study which required men to use the device for a minimum of 2-8 hours per

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I have a slight bend to the right and upward about 25 degrees and there is no pain. I cannot feel anything unusual along the shaft. My urologist has recommended transdermal verapamil. Can you comment on any recent information for this treatment?

Transdermal verapamil has been available for many years now, but unfortunately there are no published studies which have demonstrated that this preparation of verapamil results in penetration of the drug down into the diseased tunica albuginea. In fact, one study showed that there was no penetration at

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