We know that TV is absorbed into the circulation as it appears in the urine of men who use so it is likely that all of the TV is removed from the skin by absorption into the circulation within hours. Therefore, a longer duration of application is
Read more →Nonsurgical Treatment
Pentoxyffline is a medication that has been used for decades for men with lower limb vascular problems and in in vitro fertilization (IVF) laboratories for the activation of sperm. Recently, Dr. Tom Lue at UCSF has suggested that using pentoxyffline (also known as Trental and called ‘pentox’
Read more →While some medications (such as beta-blockers for high blood pressure) have been linked to the development of Peyronie’s disease there is really no good medical evidence to prove that this is the case. Indeed, there is some data that suggests that medical conditions such as high blood
Read more →Dr. Levine answers: I am delighted that some of the APDA website subscribing patients are experiencing benefits from topical verapamil however, based upon the many men I have seen who have tried topical verapamil none have noted any significant benefit what so ever. There is, of course,
Read more →As to the question of interferon vs. verapamil, both agents have been shown to be beneficial in multiple published trials. The preference of this reviewer is to use verapamil, as it is less expensive, has a very low side effect profile, and has had several more published
Read more →Dr. Levine answers: Collagenase injections are not yet available for clinical use nor have the clinical trials begun. Auxilium, the pharmaceutical company who is investigating collagenase is developing a placebo-controlled trial that must go through FDA approval before initiation. These negotiations as well as finalizing the manufacturing
Read more →It is my opinion that the injection therapy used for the treatment of ED does not cause Peyronie’s disease. What the injection therapy does do is cause a stronger erection which may be more apt to get injured during sexual intercourse. In the susceptible individual this could
Read more →Dr. Levine answers: In my opinion, the use of steroid injection is contraindicated as it can cause tissue atrophy, disruption of the normal tissue planes between the plaque and the overlying nerves and blood vessels that supply the penis, and lastly the historic papers on this therapy
Read more →Collagenase is an enzyme which breaks down collagen which is the primary component of the Peyronie’s plaque. Studies using collagenase began in the 1980s. These showed some benefit but not necessarily dramatic benefit in the early studies that were done at that time. Unfortunately because of lack
Read more →There is no evidence that Botox has a beneficial effect for Peyronie’s disease. There have been multiple reports on the use of Botox for a variety of problems, but this is a chemical which acts as neuromuscular paralyzing agent, and at this point there does not appear
Read more →