Nonsurgical Treatment

In response to your answer in November 2003 regarding topical verapamil (TV), what is the likelihood of concentration in the tunica albuginea (TA) would be had the product been applied for a longer period of time, other than 1 day; say a week or a month, etc.?

We know that TV is absorbed into the circulation as it appears in the urine of men who use so it is likely that all of the TV is removed from the skin by absorption into the circulation within hours. Therefore, a longer duration of application is

Read more

What’s the latest thinking on the possible role of some medications and invasive urological procedures in triggering or aggravating Peyronie’s disease? The link with cystoscopies and other invasive urological procedures was noted in at least one published report?

While some medications (such as beta-blockers for high blood pressure) have been linked to the development of Peyronie’s disease there is really no good medical evidence to prove that this is the case. Indeed, there is some data that suggests that medical conditions such as high blood

Read more

I’ve been using verapamil for over a year and seen great results but have reached a point now where the curve seems to not continue to heal. I’m about 70% cured and going for the full cure. Verapamil seems to cause irritation and redness, usually ten minutes after I apply it I take a shower and wash thoroughly to remove it, my pharmacist says it takes only 5 minutes to soak in. What can be done about this?

Dr. Levine answers: I am delighted that some of the APDA website subscribing patients are experiencing benefits from topical verapamil however, based upon the many men I have seen who have tried topical verapamil none have noted any significant benefit what so ever. There is, of course,

Read more

Do you know of any doctors who give collagenase injections for Peyronie’s disease?

Dr. Levine answers: Collagenase injections are not yet available for clinical use nor have the clinical trials begun. Auxilium, the pharmaceutical company who is investigating collagenase is developing a placebo-controlled trial that must go through FDA approval before initiation. These negotiations as well as finalizing the manufacturing

Read more

What are your thoughts on the upcoming collagenase injections that are supposed to be marketed in 2007-2008? Why weren’t these injections pushed before, it seems like verapamil was the hot PD drug for injections and now you are hearing more and more about collagenase. What are your predictions on the efficacy of this type of treatment or feasibility?

Collagenase is an enzyme which breaks down collagen which is the primary component of the Peyronie’s plaque. Studies using collagenase began in the 1980s. These showed some benefit but not necessarily dramatic benefit in the early studies that were done at that time. Unfortunately because of lack

Read more