Vitamin E may be used on a daily basis, but not more than 400 mg. Again there is no evidence that vitamin E truly benefits Peyronie’s disease, but it may have some potential benefits as an antioxidant and to prevent prostate disease, in particular prostate cancer.Read more →
This is a good question, as collagenase is an enzyme which breaks down collagen which is the primary component of a Peyronie’s plaque. Collagenase has been studied since the early 1980s. Recently there has been increased interest in the use of collagenase as a treatment for Peyronie’sRead more →
No. There is no evidence that topical verapamil has any proven benefit. The only study, which has been done by a group independent from the manufacturer, demonstrated no evidence of penetration of the topical verapamil gel into the underlying plaque tissue. Therefore, until properly performed and validatedRead more →
I’m a 57 year old physician with an inflammatory plaque in my mid shaft of the penis but no curvature yet. I’ve been using Caverject for about 5 years with no side effects and had some penile trauma about 2 months ago. I’m currently taking vitamin E daily and ibuprofen without any results yet. Would a trial of ultrasound therapy be worth considering?
There is no long-term data on ultrasound therapy and no study done in a randomized, controlled fashion.Read more →
I have been diagnosed with PD by a urologist 3 months ago. I am 59. He has prescribed 800 IU of vitamin E daily & also Infam-away (a hi-potency enzyme formula) capsules 6 daily on a empty stomach. Nothing has helped after taking these medicines for 3 months. Erections are very painful and curvature has developed to the left. An indentation about 1 inch below the glans has also developed. He has basically told me that there is nothing else he can do. My primary care physician admits that this is a disease that not much is known as to the whys and what will work to help the pain and hopefully stop or reverse the curvature which at present is 30-40%. I was given a pain killer to help especially if erections get too painful. Are there any over-the-counter or on the internet medicines that may help?
There are no known over-the-counter products of benefit in Peyronie’s disease. Most urologists know little about this condition and are generally not completely up-to-date on treatments and we suggest that you seek out a Peyronie’s disease expert for evaluation and a discussion of treatments.Read more →
Dr. Larry Levine from Chicago has shown very elegantly that the use of iontophoresis allows verapamil applied to the skin to be absorbed into the tunica albuginea. This is in direct contrast to the use of transdermal verapamil without iontophoresis, as it has been clearly shown thatRead more →
Dr. Levine answers: I have no experience with the use of DMSO, alone or in combination, as a form of therapy for Peyronie’s disease. I am also not familiar with any medical studies demonstrating any benefit from using DMSO, apple cider vinegar and/or castor oil for Peyronie’sRead more →
I have been using transdermal verapamil 15% by www.pdlabs.net for the last 5 months with no visible results. They told me that the cream would remodel the plaque into healthy tissue and while they couldn’t use the word cure they assured me their patented delivery system resulted in proper absorption of the medicine while other compounds were ineffective. They claimed this was one of the main reasons for so much misinformation about it. What do you make of their claims?
Dr. Mulhall answers: I am not familiar with the specific product you mention, however, here is what we know about transdermal therapy. There is not a single medical paper in the literature on the effectiveness of transdermal verapamil (go to PubMed (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi) to search for papers onRead more →
Vitamin E is probably the oldest oral therapy used in the modern era for Peyronie’s disease. Unfortunately there are no well done controlled trials demonstrating any benefit, and in a small controlled trial performed in England, no benefit was noted with the use of vitamin E forRead more →
These agents are called nutriceuticals, that is, compounds purported to be drug like but “all natural”. These compounds are not under FDA control and therefore any claims can be made without substantiation. The nutriceutical subcommittee of the Sexual Medicine Society Of North America (www.smsna.org) recently declared thatRead more →