Dr. Levine answers: Unfortunately there is little evidence that any of the pills, potions and patches which are advertised on the internet provide any benefit whatsoever, with regard to enhancement of penile girth or length. Nor are they expected to have any potential benefit in terms of treating penile deformities associated with Peyronie’s disease. I am aware that the federal government is investigating several companies for making false claims regarding sexual and penile enhancement. Unfortunately because the advertised agents are not submitted for FDA (Federal Drug Administration) approval, the regulations to control them are not under the control of the FDA, but rather under the purview of the FTC (Federal Trade Commission.) Therefore it may be for the government to help us with controlling some of these companies, which are taking advantage of men, many of whom are in dire straights because of Peyronie’s disease and men who simply want to have a larger and longer penis. At this time I can see no reason to use any of these over the counter or internet-related products as we do not know what they contain and this may result in potential toxicity. Of note, for the older man with Peyronie’s disease who is trying these agents, great care must be used in looking at all of the ingredients in these compounds as some of them contain androgens (DHEA, androstendione, testosterone) which may potentially result in more side effects than benefits for this age group. In addition, they have not been shown to have any reliable benefit. The bottom line here is save your money.