Dr. Levine answers: Peyronie’s disease is frequently associated with erectile dysfunction. Most of the time it will be a generalized reduction in rigidity, but sometimes it can be associated with what is known as “distal softening.” This can involve the area beyond scar or just the glans. The mechanism is not clearly understood, but there is increasing evidence to suggest that there may be actual infiltration of scar tissue into the vascular tissue of the penis, which prevents filling in that area resulting in the distal softening. Further investigation in this field is ongoing. If your erections are suboptimal, use of a PDE-5 inhibitor would be in order.