There is no evidence that any specific medication will activate or cause Peyronie’s disease. It is likely that the erections may have been somewhat diminished as a result of your high blood pressure, and made you more subject to activation of the Peyronie’s disease during intercourse. Most men do not recall any specific injury that may occur during sex, but it does appear that the most common trigger to activate this process in the susceptible man is mild trauma during penetrative sex or vigorous masturbation. Given that there is no evidence that any medications cause Peyronie’s disease, getting off your high blood pressure medication will not likely help, and may make it more difficult to control your high blood pressure. Therefore, please see your physician about proper blood pressure control, and your urologist with regard to the Peyronie’s disease.