Dr. Mulhall answers: In a recent study conducted by Dr. John Mulhall, more than 50% of men with Peyronie’s disease had moderate to severe depression. This is supported by information collected in the APDA poll. Thus, your feelings are not uncommon. We recommend that you see a mental health professional to discuss these feelings. The good news is pain invariably goes away but may take a year to resolve. For men with severe pain, considering intralesional injection therapy in the hands of an experienced urologist may lead to more rapid improvement of the pain. vitamin E has never been shown to be of any significant benefit although most urologists prescribe it.