In November 2004, I noticed a small bending to the left of the penis. I am currently taking vitamin E 600 units daily and I rub hydrocortisone 2% on the penis every morning. Do you think that the bending will get worse or will it stop?

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  • In November 2004, I noticed a small bending to the left of the penis. I am currently taking vitamin E 600 units daily and I rub hydrocortisone 2% on the penis every morning. Do you think that the bending will get worse or will it stop?
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It may be that you have an early form of Peyronie’s disease, which is either spontaneously recovering which occurs in less than 10% of cases, or may be responding to the oral and topical medicines that you are using. Unfortunately, there is very little evidence that vitamin E works at all and should be used at 400 units daily to avoid the reported vascular complications. Topical hydrocortisone is likely to have no benefit, and I do not recommend using it at all.

Previous In addition to verapamil, colchicine has also been shown to affect the ability of fibroblasts to make collagen. Have studies ever been done to determine whether or not local colchicine delivered via intralesional injection would have results similar, or better, than that of verapamil? Presumably this could deliver the drug to the site of the plaque, but without the systemic ill effects secondary to ingestion of oral colchicine.
Next In one of your answers you say the following: “Indeed, if treatment is started early it may prevent progression of the condition and may result in less length loss.” So taking a typical case of a lump in the middle causing an upward bend in the penis, what exactly would you use as “treatment” that is recommended early on and what is early?
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