These agents are called nutriceuticals, that is, compounds purported to be drug like but “all natural”. These compounds are not under FDA control and therefore any claims can be made without substantiation. The nutriceutical subcommittee of the Sexual Medicine Society Of North America (www.smsna.org) recently declared that there was no nutriceutical that was any better than placebo in the management of ED. While no formal analysis of Peyronie’s disease products has been conducted it is likely that the conclusions will be identical. I would urge all readers to encourage the companies making these products to subject them to rigorous, placebo-controlled studies to answer the question are they worthwhile using.