What are the implications of PD secondary to catheterization trauma as regards the causal factors of PD? Why would inflammation in the urethra lead to PD? Why would injury to a separated part of the penis find its way to the tunica?

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Dr. Mulhall answers: There exists no evidence that urethral catheterization causes Peyronie’s disease. Indeed, as you point out the “injury” would be remote from where the vast majority of the plaques are located. It is likely that the trauma that is implicated in Peyronie’s disease development is far more subtle in most men than that which may occur with urethral catheterization. Remember there are millions of men every year who are catheterized for a variety of reasons and thousands who live their lives with a catheter in place permanently and yet they appear to have no higher incidence of Peyronie’s disease than the general population.