Pentoxyffline is a medication that has been used for decades for men with lower limb vascular problems and in in vitro fertilization (IVF) laboratories for the activation of sperm. Recently, Dr. Tom Lue at UCSF has suggested that using pentoxyffline (also known as Trental and called ‘pentox’ on the street) may result in some benefit to the Peyronie’s disease patient. However, there has been no formal analysis of the effectiveness of this strategy (I refer to the section on this website on ‘interpreting the medical literature’). Thus, in my opinion, it currently ranks up there with vitamin E as a treatment. Future study may prove it of benefit but at this time it should be considered empirical and investigation.