Electromotive drug administration (EMDA) has been reported to have benefit when used for Peyronie’s disease in several publications. It appears that the best combination of drugs as reported by DiStasi is when verapamil (10 mg) and dexamethasone (4 mg) are used 3-4 times per week for at least 3 months. A control group study reported by Greenfield and Levine examined EMDA with verapamil alone versus saline alone. Both groups showed benefit with no statistically significant difference in improvement between the two groups. Overall, the improvement was fairly modest at around 10-11 degrees on average for both groups. This is in comparison to DiStasi’s report where 43% had at least 20 degrees of measured curvature improvement. As to why the saline only control group had measured improvement, it has been suggested that the electrical energy itself may have beneficial effects with respect to encouraging wound healing. Electrical current has been used in a variety of dermatologic disorders and has been known to result in accelerated wound healing. The primary benefits of EMDA are that it can be done at home, it is not painful or invasive, and it appears to have a very low rate of adverse side effects. However, it is costly and in my opinion, is best used in patients with mild to moderate degrees of deformity and/or in patients with pain, as pain resolution seems to be accelerated with EMDA.