This is a good question, as collagenase is an enzyme which breaks down collagen which is the primary component of a Peyronie’s plaque. Collagenase has been studied since the early 1980s. Recently there has been increased interest in the use of collagenase as a treatment for Peyronie’s disease as an injectable agent into the scar. The company that did the original studies has given rights to investigate this product further to another company who is in the midst of developing a protocol. No studies have been conducted to our knowledge, but will certainly be subject of reports when they become available. Collagenase is not available at this time in any part of the world, and likely will be studied first in the United States.