Will I obtain benefits if I rub collagenase instead of hydrocortisone on the place I feel the damage?

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Dr. Levine answers: If you can obtain collagenase, which to my knowledge is not at all available, it would be absolutely contraindicated to place this agent on the skin as it could cause a significant injury in that area. Injectable collagenase, in time will hopefully be available in an upcoming multi-center study to determine whether it can result in a chemical breakdown of a Peyronie’s plaque, but these studies have not begun.