A naturopathic doctor also recommends L-arginine for PD, but insists that a low dose will do nothing. No, he is not selling L-arginine. He recommends a very high dose — at least 3 grams per day and working up to 21 grams per day. Do you know of any risks to trying this?

Firstly, there is no convincing evidence that any dose of L-arginine is of any benefit for the stabilization or reversal of PD associated penile curvature. Saying that, it is a very safe agent so high doses as outlined by the other clinician is likely to cause you no significant side effects. Occasionally, patients complain of facial flushing with high dose L-arginine.