At this time, there is no FDA approved, non-surgical treatment for Peyronie’s disease, but several treatment options have been proposed, Dr. Levine’s three-armed, non surgical therapy includes pentoxifylline 400mg 3 times per day, L-arginine 1000mg twice per day, or L-citrulline 750mg twice daily. The second arm includes
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Dr. Levine answers: Intralesional verapamil remains as the most commonly used injection approach for Peyronie’s disease and appears to have fairly consistent results with respect to response. Overall, between 50-60% of men who complete a course of intralesional verapamil will have measured improvement of curvature. “Measured improvement”
Read more →Dr. Levine answers: This question addresses many issues in Peyronie’s disease, first that Peyronie’s disease can present with a variety of deformities anywhere along the shaft of the penis and there is nothing particularly unique with respect to treatment response about the curvatures which occur at the
Read more →Dr. Mulhall answers: Firstly, at 5 years the likelihood of your PD worsening is practically zero unless you re-injure your penis. There is no good evidence that Pentox is of significant benefit, although many experts use it because of some experimental (nonhuman) evidence that it has a
Read more →Dr. Mulhall answers: It is important for readers of this site to understand that I have no association or financial involvement with FastSize. To summarize the role of traction therapy for PD, firstly there exists some experimental evidence that chronic stretching of scars softens the scar and
Read more →Dr. Levine answers: As you know, erectile dysfunction (ED) frequently accompanies Peyronie’s disease and in fact up to 90% of patients have been reported some reduction of rigidity. The use of all three of the PDE-5 inhibitors (i.e. Viagra, Levitra, and Cialis) have been used successfully to
Read more →Dr. Levine answers: I am not familiar with Peyrontin and in general there have been no placebo controlled trials that have shown a benefit to using any oral agent over taking a placebo pill. This includes vitamin E, Potaba (other than reducing the plaque size), colchicine, tamoxifen,
Read more →Dr. Mulhall answers: As a scientist who has devoted more than a decade to the laboratory and clinical research in men with PD, I am very comfortable stating that there is no data that jelqing is of ANY benefit to men with PD. Indeed, I have seen
Read more →Firstly, there is no convincing evidence that any dose of L-arginine is of any benefit for the stabilization or reversal of PD associated penile curvature. Saying that, it is a very safe agent so high doses as outlined by the other clinician is likely to cause you
Read more →Vitamin E is one of the first oral agents used for the treatment of PD. However, there is no convincing evidence that alone or in combination with other agents it is of any significant benefit. Its use advocated by generations of urologists without any real understanding of
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