As to the question of interferon vs. verapamil, both agents have been shown to be beneficial in multiple published trials. The preference of this reviewer is to use verapamil, as it is less expensive, has a very low side effect profile, and has had several more publishedRead more →
Dr. Levine answers: Collagenase injections are not yet available for clinical use nor have the clinical trials begun. Auxilium, the pharmaceutical company who is investigating collagenase is developing a placebo-controlled trial that must go through FDA approval before initiation. These negotiations as well as finalizing the manufacturingRead more →
It is my opinion that the injection therapy used for the treatment of ED does not cause Peyronie’s disease. What the injection therapy does do is cause a stronger erection which may be more apt to get injured during sexual intercourse. In the susceptible individual this couldRead more →
Dr. Levine answers: In my opinion, the use of steroid injection is contraindicated as it can cause tissue atrophy, disruption of the normal tissue planes between the plaque and the overlying nerves and blood vessels that supply the penis, and lastly the historic papers on this therapyRead more →
What are your thoughts on the upcoming collagenase injections that are supposed to be marketed in 2007-2008? Why weren’t these injections pushed before, it seems like verapamil was the hot PD drug for injections and now you are hearing more and more about collagenase. What are your predictions on the efficacy of this type of treatment or feasibility?
Collagenase is an enzyme which breaks down collagen which is the primary component of the Peyronie’s plaque. Studies using collagenase began in the 1980s. These showed some benefit but not necessarily dramatic benefit in the early studies that were done at that time. Unfortunately because of lackRead more →
There is no evidence that Botox has a beneficial effect for Peyronie’s disease. There have been multiple reports on the use of Botox for a variety of problems, but this is a chemical which acts as neuromuscular paralyzing agent, and at this point there does not appearRead more →
I have had Peyronie’s disease for 1 year and 10 months and just went through Intron A injections every 2 weeks for 3 months. I have not seen any change. The Peyronie’s specialist wants to do a second wave of injections. If this did not work at all, do you think it is wise to go through a second injection battery?
In my opinion when a man goes through an injection therapy with verapamil or Intron A, and there is no visible benefit of the erect deformity of the penis following a course of 6 injections, then further injection is unlikely to result in any substantial benefit. RecentlyRead more →
There has been no study of human growth hormone (hGH) in Peyronie’s disease. I am unaware of the ability of hGH to dissolve collagen or scar. In all of the medical conferences that I have attended in the past decade that have included Peyronie’s disease research presentations,Read more →
In addition to verapamil, colchicine has also been shown to affect the ability of fibroblasts to make collagen. Have studies ever been done to determine whether or not local colchicine delivered via intralesional injection would have results similar, or better, than that of verapamil? Presumably this could deliver the drug to the site of the plaque, but without the systemic ill effects secondary to ingestion of oral colchicine.
The evidence supporting the use of oral colchicine is weak although Peyronie’s disease cells react favorable to colchicines in a test tube. The main requirement for the use of any medication as an intralesional agent is that it is safe when given intravenously (as some of theRead more →
The current recommended regimen for verapamil injections is an injection of 10 mg of verapamil diluted in 10 mL of fluid. This is administered with a standard syringe with a 5/8 inch 25-gauge needle. I have found that using a smaller gauge needle may not allow adequateRead more →