Lasers have been used as a topical application with no evidence of benefit. Lasers have been used during surgery to vaporize or cut the plaque out. Published reports on this have demonstrated no correction of deformity and in fact patients have been made worse. At this pointRead more →
There is no evidence whatsoever from properly done studies that topical verapamil provides any beneficial effects to patients with Peyronie’s disease. In fact, at least one study demonstrated that there was no evidence that verapamil, when applied over the area of plaque, actually reaches the underlying plaqueRead more →
The costs of these agents are not known to us, verapamil is inexpensive as it is a generic medication, which should cost somewhere around $10-15.00 to the physician per dose. Botox is far more expensive but it is currently in placebo-controlled trials and I would not recommendRead more →
To my knowledge, there is no contraindication to the use of Adderall with PD, but the drug to drug interaction with Trental, L-arginine and Cialis is something you should discuss with your pharmacist.Read more →
Pentoxifylline is an old oral prescription drug which is indicated to improve blood flow in the lower extremities of people with vascular disease. It has been found to have a non-specific phosphodiesterase-type inhibitor effect. This makes it somewhat like a non-specific form of Viagra. The critical partRead more →
Pentoxifylline has been shown in animal studies to potentially reduce the development of the Peyronie’s scar when the animals consumed the Pentox in their drinking water from the time that the Peyronie’s process is triggered. Pentoxifylline is indicated to enhance blood flow to the lower extremities inRead more →
There was a placebo-controlled study published in 2005 on Potaba which showed that this drug halted progression of Peyronie’s. Based on this data for those who tolerate Potaba, would this not be a reasonable addition to a verapamil injection and/or verapamil iontophoresis regimen? Would there be any contraindications to this?
You are clearly doing your homework investigating the research on Potaba which was a very well conducted placebo-controlled trial. This study did show stabilization of the disease and some reduction in plaque size in those patients who received Potaba, but there was no evidence of improvement ofRead more →
I’ve recently completed iontophoresis with 25 treatments every other day. The verapamil dosage was 20 mg/ml, using a positive charge with IOMED delivery pads. I used the verapamil only and did not include the decadron as many pharmacists, and my doctor said you can’t drive 2 drugs in with different charges (positive and negative). I saw absolutely no change in my condition, although I have lost size, and my penis seems to be hard when flaccid. Is there any advice you could give me now? I am going to try a decadron only sequence next as they said this works better on long standing scars and mine is 9 years old.
The use of iontophoresis for Peyronie’s disease has primarily focused on the Physion device from Italy. This is a device which delivers the positively charged energy via a reservoir which is filled with the verapamil with or without the decadron solution. My experience with this device isRead more →
There is no evidence that any specific medication will activate or cause Peyronie’s disease. It is likely that the erections may have been somewhat diminished as a result of your high blood pressure, and made you more subject to activation of the Peyronie’s disease during intercourse. MostRead more →
Dr. Levine answers: Fexofenadine, also known as Allegra, is an antihistamine. At this point, I am unaware of any formal studies done to examine the use of this agent for the treatment of Peyronie’s disease for any symptom whatsoever. Again it is possible that anecdotal reports areRead more →