I am 45, Peyronie’s for 5 years, stable, curve about 75 degrees. I am able to have sexual intercourse, but I worry about getting worse over time. My urologist suggests I take 2 Pentox a day, Is this OK or should I take 3? I also worry about being on the Pentox for years, if I quit after one year will I experience any worsening? Will using Pentox mess with my Immune system? I suffer from lower than normal testosterone, so I get sick easily. Should vitamin D be taken with Pentox to help in immunity?

Dr. Mulhall answers: Firstly, at 5 years the likelihood of your PD worsening is practically zero unless you re-injure your penis. There is no good evidence that Pentox is of significant benefit, although many experts use it because of some experimental (nonhuman) evidence that it has a beneficial effects on PD cells. In speaking with Dr. Tom Lue who introduced this idea, he uses it now for men with calcified plaques to reduce calcium in the plaque. I have stopped using Pentox except for the latter patients. Pentox is a safe medication and will not have an effect on your immune system. There is no data that vitamin D in combination is of any greater benefit.