In response to your answer in November 2003 regarding topical verapamil (TV), what is the likelihood of concentration in the tunica albuginea (TA) would be had the product been applied for a longer period of time, other than 1 day; say a week or a month, etc.?

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We know that TV is absorbed into the circulation as it appears in the urine of men who use so it is likely that all of the TV is removed from the skin by absorption into the circulation within hours. Therefore, a longer duration of application is unlikely to result in better tunical penetration. The use of iontophoresis can drive verapamil into the tunica however studies to prove that this results in deformity changes have not yet been conclusive.

Previous If using the suggested modalities of treatment for Peyronie’s disease, Would it help or hinder a person who is taking Coumadin for heart valve replacement?
Next There was a placebo-controlled study published in 2005 on Potaba which showed that this drug halted progression of Peyronie’s. Based on this data for those who tolerate Potaba, would this not be a reasonable addition to a verapamil injection and/or verapamil iontophoresis regimen? Would there be any contraindications to this?
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