In young men, once PD enters the chronic phase, can it convert back to the acute phase resulting in new plaque?

A small percentage of patients have reported a history of having a prior short term episode of Peyronie’s disease which corrected itself, only to come back months to years later with a plaque which does not correct itself. It does appear that repetitive injury may result in the worsening of the process resulting in a deformity which may then require more definitive treatment. Interestingly, patients who have had improvement as a result of intralesional verapamil injections have not been noted to have a recurrence with up to 15 years of follow-up.