Is it possible for iontophoresis to soften or even change any calcification that may be present in the plaque?

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I have not seen any beneficial effects of iontophoresis with verapamil and/or dexamethasone in improving plaque calcification in my experience or in the published. Therefore, in my patients who present with substantial plaque calcification iontophoresis is not recommended and in fact, there is no known non-surgical treatment for extensive plaque calcification. Typically surgery is indicated if the deformity is compromising sexual activity. The group at UCSF has suggested that the use of oral Pentoxifylline over time may change the amount of calcification within the plaque, but this has yet to be confirmed in published studies.

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