Peyronie’s disease involves the jacket tissue which surrounds the vascular tissue of the penis. This jacket is known as the tunica albuginea and remains below the skin and subcutaneous tissues. Peyronie’s disease therefore does not affect the penile skin in any way. Therefore, any changes happening on the shaft skin may represent a different problem that may be associated with certain medications or local injury. It would be wise to consider evaluation by a urologist and/or a dermatologist.