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Dr. Levine answers: At this point there is no evidence of direct association with the use of any medication and Peyronie’s disease. Historically, articles suggested in association with various medications, but these were typically case reports and due to a lack of understanding of the disease process. Many men are using a variety of antidepressants at this time, and yet there does not appear to be an increased occurrence of Peyronie’s disease in men using these medications.