Dr. Levine answers: It is unlikely that any type of urethral manipulation would trigger Peyronie’s disease unless it resulted in a downward or ventral bend of the penis. This would suggest that urethral trauma may have activated some inflammation and scarring on the undersurface of the penis causing the downward curve. Most men who present with Peyronie’s disease have either an upward or lateral curve, which may have been triggered by other silent trauma. Therefore it is highly unlikely that this was due to any type of urethral manipulation including cystoscopy.
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