By and large if the calcification is extensive, and involves virtually the entire plaque in the area of the deformity, then any intralesional injection approach does not work as these drugs have no effect upon bone. Furthermore the needle is unlikely to pierce the calcification. On the other hand, when there is stippled or scattered calcification in the plaque there has been some reported success with intralesional verapamil injections, particularly when this is combined with traction therapy using the Fast Size device. There is also evidence that patients who have a calcified plaque associated with painful erections that when injections of verapamil are used around the edges of the plaque that this may accelerate stabilization of the plaque, and reduce the pain.
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