When a plaque has calcified is it a waste of time and money to treat with intralesional verapamil or interferon injections?

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By and large if the calcification is extensive, and involves virtually the entire plaque in the area of the deformity, then any intralesional injection approach does not work as these drugs have no effect upon bone. Furthermore the needle is unlikely to pierce the calcification. On the other hand, when there is stippled or scattered calcification in the plaque there has been some reported success with intralesional verapamil injections, particularly when this is combined with traction therapy using the Fast Size device. There is also evidence that patients who have a calcified plaque associated with painful erections that when injections of verapamil are used around the edges of the plaque that this may accelerate stabilization of the plaque, and reduce the pain.

Previous What is your opinion on the use of intralesional verapamil for young patients who have had the disease for over three years, but have little or no calcification in the plaque? If it is sensible to try verapamil, would it be better to use iontophoresis? Would traction therapy further enhance the benefits?
Next Why is the VED not recognized by most urologists as being a viable treatment for PD?
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